منابع مشابه
Novel derivatives of polymyxins.
Polymyxin B and colistin (polymyxin E) are bactericidal pentacationic lipopeptides that act specifically on Gram-negative bacteria, first by disrupting their outermost permeability barrier, the outer membrane (OM), and then damaging the cytoplasmic membrane. Both were discovered in the mid-1950s and subsequently used in intravenous therapy, but soon largely abandoned because of nephrotoxicity. ...
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Although the value of polymyxins B and E in the treatment of infections with Gram-negative bacilli is well recognized, they are not usually used unless the causal organisms are insensitive to antibiotics with wider activity. In consequence, sensitivity tests for them are not common laboratory procedures and it is not generally appreciated that the usual methods are not entirely satisfactory. Ju...
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We give an overview of the running time analysis of the random divide-and-conquer algorithm FIND or QUICKSELECT. The results concern moments, distribution of FIND’s running time, the limiting distribution, a stochastic bound and the key: a stochastic fixed point equation.
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In a recent article, Garonzik et al. (4) importantly advanced our knowledge of the pharmacokinetics (PK) of colistin methanesulfonate (CMS) and the active drug that it forms, colistin. In their elegant population PK study of critically ill patients, the authors demonstrated that creatinine clearance (CLCR) significantly affects the total body clearance of CMS and colistin (4). It is important t...
متن کاملBacitracin, Glycopeptide Antibiotics, and the Polymyxins
Bacitracin and the polymyxins are polypeptide antibiotics. They are relatively toxic drugs and have had only limited use in chemotherapy until recently. Vancomycin, a glycopeptide, although not without side effects, is widely used.Teicoplanin is a new glycopeptide antibiotic that may be beneficial against certain infections caused by gram-positive organisms. The mechanisms of action of this gro...
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ژورنال
عنوان ژورنال: Clinical Microbiology Reviews
سال: 2008
ISSN: 0893-8512,1098-6618
DOI: 10.1128/cmr.00006-08